Switch #: SWTI000137

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y497 in the PTB-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Insulin receptor substrate 1 (IRS1) protein.

Participants:
(1) Interleukin-4 receptor subunit alpha (IL4R)
(2) Insulin receptor substrate 1 (IRS1)

(1) FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation.
Nelms et al. Immunity (1998)

(2) Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Zhou et al. Nat. Struct. Biol. (1996)

Other switches involving participants
Insulin receptor substrate 1 (IRS1) - 2 more (view)
Interleukin-4 receptor subunit alpha (IL4R) - 7 more (view)

Other switches involving interfaces
LIG_PTB_Phospho_1 - 18 more (view)
PTB domain (IRS-1 type) - 12 more (view)