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Switch #:
SWTI000136
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y364 in the PTB-binding motif of Interleukin-2 receptor subunit beta (IL2RB) induces binding to the SHC-transforming protein 1 (SHC1) protein.

Participants:
(1) Interleukin-2 receptor subunit beta (IL2RB)
(2) SHC-transforming protein 1 (SHC1)

Interactions
Interaction #1 IL2RB - SHC1

Interfaces
(1) LIG_PTB_Phospho_1 motif (358CFTNQGY364) in Interleukin-2 receptor subunit beta (IL2RB)
(2) Phosphotyrosine interaction domain (PTB/PID) (162-318) in SHC-transforming protein 1 (SHC1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y364 on Interleukin-2 receptor subunit beta (IL2RB)) of the Interleukin-2 receptor subunit beta (IL2RB) LIG_PTB_Phospho_1 motif - SHC-transforming protein 1 (SHC1) Phosphotyrosine interaction domain (PTB/PID) interaction

Context
Switch localisation
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex
References

(1) Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling.
Ravichandran et al. Proc. Natl. Acad. Sci. U.S.A. (1996)

See also

Other switches involving participants
SHC-transforming protein 1 (SHC1) - 15 more (view)
Interleukin-2 receptor subunit beta (IL2RB) - 4 more (view)

Other switches involving interfaces
LIG_PTB_Phospho_1 - 18 more (view)
Phosphotyrosine interaction domain (PTB/PID) - 14 more (view)


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