Switch #: SWTI000135

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y1328 in the PTB-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.

Participants:
(1) Receptor tyrosine-protein kinase erbB-3 (ERBB3)
(2) SHC-transforming protein 1 (SHC1)

(1) Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera.
Prigent et al. EMBO J. (1994)

Other switches involving participants
SHC-transforming protein 1 (SHC1) - 15 more (view)
Receptor tyrosine-protein kinase erbB-3 (ERBB3) - 11 more (view)

Other switches involving interfaces
LIG_PTB_Phospho_1 - 18 more (view)
Phosphotyrosine interaction domain (PTB/PID) - 14 more (view)