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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: PFAM:PF03623 (5 hits) x
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x  Coloured by switch type.
  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
LIG_FAT_LD_1LIG_SH2_IB


ProteinStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

LIG_FAT_LD_1 - The paxillin LD motif is recognized by FAK and other focal adhesion proteins mainly involved in cytoskeletal regulation
PAXI_HUMAN412BinaryPre‑translationalAlternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).
details

LIG_SH2_IB -
PAXI_HUMAN118121BinaryPre‑translationalAlternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Ras GTPase-activating protein 1 (RASA1).
details
PAXI_HUMAN118121BinaryPre‑translationalAlternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).
details
PAXI_HUMAN3134BinaryPre‑translationalAlternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).
details
PAXI_HUMAN118121BinaryPre‑translationalAlternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Ras GTPase-activating protein 1 (RASA1).
details
           
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