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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P29351 (2 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
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LIG_TYR_ITIM


ProteinStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

LIG_TYR_ITIM - ITIM (immunoreceptor tyrosine-based inhibitory motif). Phosphorylation of the ITIM motif, found in the cytoplasmic tail of some inhibitory receptors (KIRs) that bind MHC Class I, leads to the recruitment and activation of a protein tyrosine phosphatase.
SIG12_MOUSE430435BinaryPre‑translationalAlternative splicing removes the ITIM (immunoreceptor tyrosine-based inhibitory motif) of Sialic acid-binding Ig-like lectin 12 (Siglec12), abrogating binding to Tyrosine-protein phosphatase non-receptor type 6 (Ptpn6).
details
SIG12_MOUSE430435BinaryPre‑translationalAlternative splicing removes the ITIM (immunoreceptor tyrosine-based inhibitory motif) of Sialic acid-binding Ig-like lectin 12 (Siglec12), abrogating binding to Tyrosine-protein phosphatase non-receptor type 6 (Ptpn6).
details
           
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