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| Cell cycle | G1/S DNA Damage Checkpoints | HIF-1 signaling pathway |
| Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
Cell cycle (KEGG - hsa04110) | ||||||||
| LIG_TAZ2 | P53_HUMAN | 19 | 25 | Cumulative | Rheostatic | Multisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP). | Curated | |
G1/S DNA Damage Checkpoints (Reactome - 69615) | ||||||||
| LIG_TAZ2 | P53_HUMAN | 19 | 25 | Cumulative | Rheostatic | Multisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP). | Curated | |
HIF-1 signaling pathway (KEGG - hsa04066) | ||||||||
| LIG_TAZ1 | HIF1A_HUMAN | 792 | 795 | Binary | Physicochemical compatibility | Under normoxic conditions interaction of Hypoxia-inducible factor 1-alpha (HIF1A) with transcriptional coactivators such as CREB-binding protein (Crebbp) is inhibited by hydroxylation of N803. | Curated | |
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen (Reactome - 1234174) | ||||||||
| LIG_TAZ1 | HIF1A_HUMAN | 792 | 795 | Binary | Physicochemical compatibility | Under normoxic conditions interaction of Hypoxia-inducible factor 1-alpha (HIF1A) with transcriptional coactivators such as CREB-binding protein (Crebbp) is inhibited by hydroxylation of N803. | Curated | |