switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: PFAM:PF02296 (2 hits) x

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Curated inferred

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Motif

Protein

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Information

Evidence

Endocytosis (KEGG - hsa04144)
LIG_AP2alpha_2	DAB2_HUMAN	293	295	Binary	Pre‑translational	Alternative splicing removes the AP2alpha-binding motifs of Disabled homolog 2 (DAB2), abrogating binding to AP-2 complex subunit alpha-2 (AP2A2). The p67 splice variant of Dab1 (also known as Isoform 2 of Disabled homolog 2 (DAB2)) does not localise to vesicles as it fails to bind the AP-2 complex.	details	Inferred
LIG_AP2alpha_2	DAB2_HUMAN	298	300	Binary	Pre‑translational	Alternative splicing removes the AP2alpha-binding motifs of Disabled homolog 2 (DAB2), abrogating binding to AP-2 complex subunit alpha-2 (AP2A2). The p67 splice variant of Dab1 (also known as Isoform 2 of Disabled homolog 2 (DAB2)) does not localise to vesicles as it fails to bind the AP-2 complex.	details	Inferred