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Switch #:
SWTI000573
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the AP2alpha-binding motifs of Disabled homolog 2 (DAB2), abrogating binding to AP-2 complex subunit alpha-2 (AP2A2). The p67 splice variant of Dab1 (also known as Isoform 2 of Disabled homolog 2 (DAB2)) does not localise to vesicles as it fails to bind the AP-2 complex.

Participants:
(1) Disabled homolog 2 (DAB2)
(2) AP-2 complex subunit alpha-2 (AP2A2)

Interactions
Interaction #1 DAB2 - AP2A2

Interfaces
(1) LIG_AP2alpha_2 motif (293DPF295) in Disabled homolog 2 (DAB2)
(2) Alpha adaptin AP2, C-terminal domain (826-934) in AP-2 complex subunit alpha-2 (AP2A2)

Interaction Regulation
Alternative splicing Abrogation of the Disabled homolog 2 (DAB2) LIG_AP2alpha_2 motif - AP-2 complex subunit alpha-2 (AP2A2) Alpha adaptin AP2, C-terminal domain interaction

Context
Switch localisation
ELM curated: cytosol, clathrin-coated endocytic vesicle


Switch pathways
Inferred: Endocytosis
References

(1) Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2.
Morris et al. Traffic (2001)

See also

Other switches involving participants
AP-2 complex subunit alpha-2 (AP2A2) - 3 more (view)
Disabled homolog 2 (DAB2) - 1 more (view)

Other switches involving interfaces
LIG_AP2alpha_2 - 3 more (view)
Alpha adaptin AP2, C-terminal domain - 3 more (view)


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