Switch #: SWTI000572

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the mitochondrial localisation signal (MLS) motif of Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A) and import into the mitochondria.

Participants:
(1) Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT)
(2) Mitochondrial import receptor subunit TOM70 (TOMM70A)

(1) The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential expression of the isoforms and characterization of a cDNA encoding the mitochondrial species.
Ladner et al. J. Biol. Chem. (1997)

Other switches involving participants
Mitochondrial import receptor subunit TOM70 (TOMM70A) - 7 more (view)

Other switches involving interfaces
ELM:TRG_MLS - 7 more (view)
Tetratricopeptide repeat - 8 more (view)