Switch #: SWTI000571

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the nuclear localisation signal (NLS) motif of N-glycosylase/DNA lyase (OGG1), abrogating binding to Importin subunit alpha-1 (KPNA1) and import into the nucleus. OGG1-1a (also known as Isoform Alpha of N-glycosylase/DNA lyase (OGG1)) has a C-terminal NLS motif that is absent in OGG1-2a (also known as Isoform Beta of N-glycosylase/DNA lyase (OGG1)) . Both have a weak mitochondrial localisation signal (MLS) in the N-terminal.

Participants:
(1) N-glycosylase/DNA lyase (OGG1)
(2) Importin subunit alpha-1 (KPNA1)

(1) Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs.
Nishioka et al. Mol. Biol. Cell (1999)

Other switches involving participants
Importin subunit alpha-1 (KPNA1) - 9 more (view)

Other switches involving interfaces
TRG_NLS_MonoExtN_4 - 10 more (view)
Armadillo/beta-catenin-like repeat - 16 more (view)