About Help Definitions Submit Search Analyse Browse Home


Switch #:
SWTI000571
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the nuclear localisation signal (NLS) motif of N-glycosylase/DNA lyase (OGG1), abrogating binding to Importin subunit alpha-1 (KPNA1) and import into the nucleus. OGG1-1a (also known as Isoform Alpha of N-glycosylase/DNA lyase (OGG1)) has a C-terminal NLS motif that is absent in OGG1-2a (also known as Isoform Beta of N-glycosylase/DNA lyase (OGG1)) . Both have a weak mitochondrial localisation signal (MLS) in the N-terminal.

Participants:
(1) N-glycosylase/DNA lyase (OGG1)
(2) Importin subunit alpha-1 (KPNA1)

Interactions
Interaction #1 OGG1 - KPNA1

Interfaces
(1) TRG_NLS_MonoExtN_4 motif (332PPAKRRKG339) in N-glycosylase/DNA lyase (OGG1)
(2) Armadillo/beta-catenin-like repeat (115-451) in Importin subunit alpha-1 (KPNA1)

Interaction Regulation
Alternative splicing Abrogation of the N-glycosylase/DNA lyase (OGG1) TRG_NLS_MonoExtN_4 motif - Importin subunit alpha-1 (KPNA1) Armadillo/beta-catenin-like repeat interaction

Context
References

(1) Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs.
Nishioka et al. Mol. Biol. Cell (1999)

See also

Other switches involving participants
Importin subunit alpha-1 (KPNA1) - 9 more (view)

Other switches involving interfaces
TRG_NLS_MonoExtN_4 - 10 more (view)
Armadillo/beta-catenin-like repeat - 16 more (view)




Loading visualisation

           
Please send any suggestions/comments to: switches@elm.eu.org