Switch #: SWTI000570

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the mitochondrial localisation signal (MLS) motif of Glutaredoxin-2, mitochondrial (GLRX2), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A) and import into mitochondria. The Grx2a isoform Isoform Grx2a of Glutaredoxin-2, mitochondrial (GLRX2) is localised to the mitochondria whereas the Isoform Grx2b of Glutaredoxin-2, mitochondrial (GLRX2) is localised to the perinuclear region.

Participants:
(1) Glutaredoxin-2, mitochondrial (GLRX2)
(2) Mitochondrial import receptor subunit TOM70 (TOMM70A)

(1) Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms.
Lundberg et al. J. Biol. Chem. (2001)

Other switches involving participants
Mitochondrial import receptor subunit TOM70 (TOMM70A) - 7 more (view)

Other switches involving interfaces
ELM:TRG_MLS - 7 more (view)
Tetratricopeptide repeat - 8 more (view)