switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: PFAM:PF03623 (11 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Chemokine signaling pathway	Focal adhesion	Leukocyte transendothelial migration
Regulation of actin cytoskeleton	VEGF signaling pathway

Motif

Protein

Start

End

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Information

Evidence

Chemokine signaling pathway (KEGG - hsa04062)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	118	121	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	31	34	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
Focal adhesion (KEGG - hsa04510)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	118	121	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	31	34	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
Leukocyte transendothelial migration (KEGG - hsa04670)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred
Regulation of actin cytoskeleton (KEGG - hsa04810)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	118	121	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	31	34	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
VEGF signaling pathway (KEGG - hsa04370)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred