switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:O60331 (2 hits) x

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Curated inferred

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Information

Evidence

Endocytosis (KEGG - hsa04144)
TRG_ENDOCYTIC_2	PI51C_HUMAN	649	652	Binary	Physicochemical compatibility	Phosphorylation of S645 near the AP2-binding motif of Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) by Cyclin-dependent kinase 5 (Cdk5) inhibits its interaction with AP-2 complex subunit mu (AP2M1).	details	Inferred
Focal adhesion (KEGG - hsa04510)
LIG_PTB_Talin	PI51C_HUMAN	650	653	Binary	Physicochemical compatibility	Phosphorylation of S650 in the PTB-binding motif of Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) blocks its interaction with Talin-1 (TLN1). Phosphorylation of Y649 by Src kinase enhances the interaction, possibly indirectly by inhibiting S650 phosphorylation.	details	Inferred