Switch #: SWTI000614

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S645 near the AP2-binding motif of Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) by Cyclin-dependent kinase 5 (Cdk5) inhibits its interaction with AP-2 complex subunit mu (AP2M1).

Participants:
(1) Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C)
(2) AP-2 complex subunit mu (AP2M1)

(1) Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendage.
Thieman et al. J. Biol. Chem. (2009)

(2) Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis.
Nakano-Kobayashi et al. EMBO J. (2007)

Other switches involving participants
AP-2 complex subunit mu (AP2M1) - 15 more (view)
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) - 1 more (view)

Other switches involving interfaces
TRG_ENDOCYTIC_2 - 21 more (view)
Adaptor complexes medium subunit family - 21 more (view)