switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P26450 (8 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

B cell receptor signaling pathway	Fc epsilon RI signaling pathway	Fc gamma R-mediated phagocytosis
Phosphatidylinositol signaling system

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

B cell receptor signaling pathway (KEGG - mmu04662)
LIG_SH2_IIA	SHIP1_HUMAN	918	921	Binary	Pre‑translational	Alternative splicing partially removes the SH2-binding motif of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inpp5d), partially inhibiting binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1).	details	Inferred
LIG_SH2_IIA	SHIP1_HUMAN	918	921	Binary	Pre‑translational	Alternative splicing partially removes the SH2-binding motif of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inpp5d), partially inhibiting binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1).	details	Inferred
Fc epsilon RI signaling pathway (KEGG - mmu04664)
LIG_SH2_IIA	SHIP1_HUMAN	918	921	Binary	Pre‑translational	Alternative splicing partially removes the SH2-binding motif of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inpp5d), partially inhibiting binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1).	details	Inferred
LIG_SH2_IIA	SHIP1_HUMAN	918	921	Binary	Pre‑translational	Alternative splicing partially removes the SH2-binding motif of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inpp5d), partially inhibiting binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1).	details	Inferred
Fc gamma R-mediated phagocytosis (KEGG - mmu04666)
LIG_SH2_IIA	SHIP1_HUMAN	918	921	Binary	Pre‑translational	Alternative splicing partially removes the SH2-binding motif of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inpp5d), partially inhibiting binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1).	details	Inferred
LIG_SH2_IIA	SHIP1_HUMAN	918	921	Binary	Pre‑translational	Alternative splicing partially removes the SH2-binding motif of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inpp5d), partially inhibiting binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1).	details	Inferred
Phosphatidylinositol signaling system (KEGG - mmu04070)
LIG_SH2_IIA	SHIP1_HUMAN	918	921	Binary	Pre‑translational	Alternative splicing partially removes the SH2-binding motif of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inpp5d), partially inhibiting binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1).	details	Inferred
LIG_SH2_IIA	SHIP1_HUMAN	918	921	Binary	Pre‑translational	Alternative splicing partially removes the SH2-binding motif of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inpp5d), partially inhibiting binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1).	details	Inferred