switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P49023 (11 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Chemokine signaling pathway	Focal adhesion	Leukocyte transendothelial migration
Regulation of actin cytoskeleton	VEGF signaling pathway

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

Chemokine signaling pathway (KEGG - hsa04062)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	118	121	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	31	34	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
Focal adhesion (KEGG - hsa04510)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	118	121	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	31	34	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
Leukocyte transendothelial migration (KEGG - hsa04670)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred
Regulation of actin cytoskeleton (KEGG - hsa04810)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	118	121	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	31	34	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
VEGF signaling pathway (KEGG - hsa04370)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred