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| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
APC/C-mediated degradation of cell cycle proteins (Reactome - 174143) | ||||||||
| DEG_APCC_DBOX_3 | NEK2_HUMAN | 423 | 445 | Binary | Pre‑translational | Alternative splicing removes the extended D-box degron motif of Serine/threonine-protein kinase Nek2 (NEK2), abrogating binding to Cell division cycle protein 20 homolog (CDC20). NEK2-A is targeted by APC/C-Cdc20 in early mitosis whereas Isoform Nek2B of Serine/threonine-protein kinase Nek2 (NEK2) persists into late mitosis. Degradation of Isoform Nek2A of Serine/threonine-protein kinase Nek2 (NEK2) may be necessary to allow re-establishment of the intercentriolar linkage in late mitosis. | Curated | |