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Alternative splicing removes the extended D-box degron motif of Serine/threonine-protein kinase Nek2 (NEK2), abrogating binding to Cell division cycle protein 20 homolog (CDC20). NEK2-A is targeted by APC/C-Cdc20 in early mitosis whereas Isoform Nek2B of Serine/threonine-protein kinase Nek2 (NEK2) persists into late mitosis. Degradation of Isoform Nek2A of Serine/threonine-protein kinase Nek2 (NEK2) may be necessary to allow re-establishment of the intercentriolar linkage in late mitosis.

(1) Serine/threonine-protein kinase Nek2 (NEK2)
(2) Cell division cycle protein 20 homolog (CDC20)

Interaction #1 NEK2 - CDC20

(1) ELM:DEG_APCC_DBOX_3 motif (423RAQALSDIEKNYQLKSRQILGMR445) in Serine/threonine-protein kinase Nek2 (NEK2)
(2) WD domain, G-beta repeat (182-480) in Cell division cycle protein 20 homolog (CDC20)

Interaction Regulation
Alternative splicing Abrogation of the Serine/threonine-protein kinase Nek2 (NEK2) DEG_APCC_DBOX_3 motif - Cell division cycle protein 20 homolog (CDC20) WD domain, G-beta repeat interaction


(1) APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box.
Hames et al. EMBO J. (2001)

See also

Other switches involving participants
Cell division cycle protein 20 homolog (CDC20) - 3 more (view)
Serine/threonine-protein kinase Nek2 (NEK2) - 2 more (view)

Other switches involving interfaces
WD domain, G-beta repeat - 36 more (view)

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