Switch #: SWTI000469

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the PP1-docking motif of Serine/threonine-protein kinase Nek2 (NEK2), abrogating binding to Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA). Isoform Nek2A of Serine/threonine-protein kinase Nek2 (NEK2) is localised at centrosomes and causes centrosome splitting. Isoform Nek2B of Serine/threonine-protein kinase Nek2 (NEK2) is expressed at a different point in the cell cycle and required for assembly/maintenance of centrosomes.

Participants:
(1) Serine/threonine-protein kinase Nek2 (NEK2)
(2) Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)

(1) NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.
Helps et al. Biochem. J. (2000)

Other switches involving participants
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) - 1 more (view)
Serine/threonine-protein kinase Nek2 (NEK2) - 2 more (view)

Other switches involving interfaces
DOC_PP1 - 4 more (view)
Calcineurin-like phosphoesterase - 5 more (view)