Switches.ELM

Switch #:

SWTI000471

Switch type:
Binary

Description:
Alternative splicing removes the extended SCF-TrCP degron motif of Bcl-2-like protein 11 (BCL2L11), abrogating binding to F-box/WD repeat-containing protein 1A (BTRC). Upon mitogen survival signals, RPS6KA1 and RPS6KA2 kinases are up-regulated and rapidly phosphorylate the three serines of Isoform Bim(EL) of Bcl-2-like protein 11 (BCL2L11). This facilitates the binding of betaTrCP and subsequent ubiquitination and degradation of Isoform Bim(EL) of Bcl-2-like protein 11 (BCL2L11).

Participants:
(1) Bcl-2-like protein 11 (BCL2L11)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interactions

Interaction #1 BCL2L11 - BTRC

Interfaces
(1) ELM:DEG_SCF_TRCP1_2 motif (₉₃SSGYFS₉₈) in Bcl-2-like protein 11 (BCL2L11)
(2) WD domain, G-beta repeat_(301-590) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
Alternative splicing Abrogation of the Bcl-2-like protein 11 (BCL2L11) DEG_SCF_TRCP1_2 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction

Context

Switch localisation

References

(1) betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.
Dehan et al. Mol. Cell (2009)