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Alternative splicing removes the extended SCF-TrCP degron motif of Bcl-2-like protein 11 (BCL2L11), abrogating binding to F-box/WD repeat-containing protein 1A (BTRC). Upon mitogen survival signals, RPS6KA1 and RPS6KA2 kinases are up-regulated and rapidly phosphorylate the three serines of Isoform Bim(EL) of Bcl-2-like protein 11 (BCL2L11). This facilitates the binding of betaTrCP and subsequent ubiquitination and degradation of Isoform Bim(EL) of Bcl-2-like protein 11 (BCL2L11).

(1) Bcl-2-like protein 11 (BCL2L11)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interaction #1 BCL2L11 - BTRC

(1) ELM:DEG_SCF_TRCP1_2 motif (93SSGYFS98) in Bcl-2-like protein 11 (BCL2L11)
(2) WD domain, G-beta repeat (301-590) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
Alternative splicing Abrogation of the Bcl-2-like protein 11 (BCL2L11) DEG_SCF_TRCP1_2 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction

Switch localisation

(1) betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.
Dehan et al. Mol. Cell (2009)

See also

Other switches involving participants
F-box/WD repeat-containing protein 1A (BTRC) - 17 more (view)
Bcl-2-like protein 11 (BCL2L11) - 1 more (view)

Other switches involving interfaces
WD domain, G-beta repeat - 36 more (view)
ELM:DEG_SCF_TRCP1_2 - 2 more (view)

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