About Help Definitions Submit Search Analyse Browse Home

Switch #:
Switch type:
Switch subtype:

Alternative splicing removes the mitochondrial localisation signal (MLS) motif of Carnitine O-acetyltransferase (CRAT), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A). As a result, Isoform SM-1200 of Carnitine O-acetyltransferase (CRAT), which lacks the MLS, is located in peroxisomes due to a PTS1 motif in its C-terminus.

(1) Carnitine O-acetyltransferase (CRAT)
(2) Mitochondrial import receptor subunit TOM70 (TOMM70A)

Interaction #1 CRAT - TOMM70A

(1) ELM:TRG_MLS motif (1MLAFAARTVVKPLGFLKPFSL21) in Carnitine O-acetyltransferase (CRAT)
(2) Tetratricopeptide repeat (114-578) in Mitochondrial import receptor subunit TOM70 (TOMM70A)

Interaction Regulation
Alternative splicing Abrogation of the Carnitine O-acetyltransferase (CRAT) TRG_MLS motif - Mitochondrial import receptor subunit TOM70 (TOMM70A) Tetratricopeptide repeat interaction


(1) Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism.
et al. J. Lipid Res. (2010)

(2) Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations.
Corti et al. Biochem. J. (1994)

See also

Other switches involving participants
Mitochondrial import receptor subunit TOM70 (TOMM70A) - 7 more (view)

Other switches involving interfaces
ELM:TRG_MLS - 7 more (view)
Tetratricopeptide repeat - 8 more (view)

Loading visualisation

Please send any suggestions/comments to: switches@elm.eu.org