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Switch #:
SWTI000473
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing alters the flanking regions of the PTB-binding motif of Isoform Beta-1D of Integrin beta-1 (ITGB1), inducing higher affinity binding to Talin-1 (TLN1). Alteration of residue 788 from G to Q and alteration of residue 786 from A to P increases the binding affinity from 491 micromolar in the canonical Isoform Beta-1A of Integrin beta-1 (ITGB1) to 95 micromolar in Isoform Beta-1D of Integrin beta-1 (ITGB1).

Participants:
(1) Isoform Beta-1D of Integrin beta-1 (ITGB1)
(2) Talin-1 (TLN1)

Interactions
Interaction #1 ITGB1 - TLN1

Interfaces
(1) ELM:LIG_Talin motif (775WDTQENPIYKS785) in Isoform Beta-1D of Integrin beta-1 (ITGB1)
(2) PTB domain (IRS-1 type) (310-401) in Talin-1 (TLN1)

Interaction Regulation
Alternative splicing Inhibition of the Isoform Beta-1D of Integrin beta-1 (ITGB1) LIG_Talin motif - Talin-1 (TLN1) PTB domain (IRS-1 type) interaction

Additional Information
Affinity : ITB-A isoform: 491 µM, ITB-D isoform: 95 µM
Context
References

(1) Structural diversity in integrin/talin interactions.
Anthis et al. Structure (2010)

See also

Other switches involving participants
Talin-1 (TLN1) - 3 more (view)
Isoform Beta-1D of Integrin beta-1 (ITGB1) - 1 more (view)

Other switches involving interfaces
PTB domain (IRS-1 type) - 12 more (view)
ELM:LIG_Talin - 2 more (view)




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