Switches.ELM

Switch #:

SWTI000474

Switch type:
Binary

Description:
Alternative splicing alters the flanking regions of the PTB-binding motif of Isoform Beta-1D of Integrin beta-1 (ITGB1), inducing higher affinity binding to Talin-2 (TLN2). The alteration of residue 788 from G to Q and alteration of residue 786 from A to P increases the binding affinity from 652 micromolar in the canonical Isoform Beta-1A of Integrin beta-1 (ITGB1) to 36 micromolar in Isoform Beta-1D of Integrin beta-1 (ITGB1).

Participants:
(1) Isoform Beta-1D of Integrin beta-1 (ITGB1)
(2) Talin-2 (TLN2)

Interactions

Interaction #1 ITGB1 - TLN2

Interfaces
(1) ELM:LIG_Talin motif (₇₇₅WDTQENPIYKS₇₈₅) in Isoform Beta-1D of Integrin beta-1 (ITGB1)
(2) PTB domain (IRS-1 type)_(313-404) in Talin-2 (TLN2)

Interaction Regulation
Alternative splicing Inhibition of the Isoform Beta-1D of Integrin beta-1 (ITGB1) LIG_Talin motif - Talin-2 (TLN2) PTB domain (IRS-1 type) interaction

Additional Information
Affinity : ITB-A isoform: 652 µM, ITB-D isoform: 36 µM

Context

Switch pathways

References

(1) Structural diversity in integrin/talin interactions.
Anthis et al. Structure (2010)