Switch #: SWTI000475

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing strongly inhibits the binding of the filamin-binding motif of Integrin beta-1 (ITGB1) to Filamin-A (FLNA), primarily due to the alteration of A to P it seems.

Participants:
(1) Integrin beta-1 (ITGB1)
(2) Filamin-A (FLNA)

(1) Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.
van der Flier et al. J. Cell Biol. (2002)

(2) The molecular basis of filamin binding to integrins and competition with talin.
Kiema et al. Mol. Cell (2006)

Other switches involving participants
Filamin-A (FLNA) - 2 more (view)
Integrin beta-1 (ITGB1) - 1 more (view)

Other switches involving interfaces
Filamin/ABP280 repeat - 3 more (view)
ELM:LIG_Filamin_2 - 1 more (view)