Switches.ELM

Switch #:

SWTI000476

Switch type:
Binary

Description:
Alternative splicing strongly inhibits the binding of the filamin-binding motif of Integrin beta-1 (ITGB1) to Filamin-B (FLNB), primarily due to the alteration of A to P it seems. Splicing of FLNB also affects this interaction.

Participants:
(1) Integrin beta-1 (ITGB1)
(2) Filamin-B (FLNB)

Interactions

Interaction #1 ITGB1 - FLNB

Interfaces
(1) ELM:LIG_Filamin_2 motif (₇₈₃YKSAVTTVV₇₉₁) in Integrin beta-1 (ITGB1)
(2) Filamin/ABP280 repeat_(2285-2372) in Filamin-B (FLNB)

Interaction Regulation
Alternative splicing Inhibition of the Integrin beta-1 (ITGB1) LIG_Filamin_2 motif - Filamin-B (FLNB) Filamin/ABP280 repeat interaction

Context

Switch localisation
Curated: cytoplasmic side of plasma membrane

Switch pathways

Inferred: Focal adhesion

References

(1) Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.
van der Flier et al. J. Cell Biol. (2002)