About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: PFAM:PF02135 (2 hits) x
submit


x  Coloured by switch type.
  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
Cellular tumor antigen p53Hypoxia-inducible factor 1-alpha


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Cellular tumor antigen p53 - TP53 -  Homo sapiens
LIG_TAZ21925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details

Hypoxia-inducible factor 1-alpha - HIF1A -  Homo sapiens
LIG_TAZ1792795BinaryPhysicochemical compatibilityUnder normoxic conditions interaction of Hypoxia-inducible factor 1-alpha (HIF1A) with transcriptional coactivators such as CREB-binding protein (Crebbp) is inhibited by hydroxylation of N803.
details
           
Please send any suggestions/comments to: switches@elm.eu.org