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| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| Motif | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
Disabled homolog 2 - DAB2 - Homo sapiens | |||||||
| LIG_AP2alpha_2 | 293 | 295 | Binary | Pre‑translational | Alternative splicing removes the AP2alpha-binding motifs of Disabled homolog 2 (DAB2), abrogating binding to AP-2 complex subunit alpha-2 (AP2A2). The p67 splice variant of Dab1 (also known as Isoform 2 of Disabled homolog 2 (DAB2)) does not localise to vesicles as it fails to bind the AP-2 complex. | ||
| LIG_AP2alpha_2 | 298 | 300 | Binary | Pre‑translational | Alternative splicing removes the AP2alpha-binding motifs of Disabled homolog 2 (DAB2), abrogating binding to AP-2 complex subunit alpha-2 (AP2A2). The p67 splice variant of Dab1 (also known as Isoform 2 of Disabled homolog 2 (DAB2)) does not localise to vesicles as it fails to bind the AP-2 complex. | ||
Synaptojanin-1 - SYNJ1 - Homo sapiens | |||||||
| LIG_AP2alpha_2 | 1323 | 1325 | Binary | Pre‑translational | Alternative splicing removes the AP2alpha-binding motif of Synaptojanin-1 (SYNJ1), abrogating binding to AP-2 complex subunit alpha-2 (AP2A2). Isoform Synaptojanin-170 of Synaptojanin-1 (SYNJ1) is associated with clathrin-mediated endocytosis as a negative regulator of coat-membrane interaction. This isoform is virtually absent from mature neuronal synapses, where clathrin-mediated endocytosis plays a critical role and where Isoform Synaptojanin-145 of Synaptojanin-1 (SYNJ1) is by far the major synaptojanin isoform. Isoform Synaptojanin-145 of Synaptojanin-1 (SYNJ1) may be recruited early to clathrin-coated pits of synapses, either indirectly by adaptors that bind clathrin and AP-2, such as Amphiphysin (AMPH), or by interactions of endophilin family dimers with synaptic vesicle cargo, such as the vesicular glutamate transport. | ||
| LIG_AP2alpha_2 | 1555 | 1557 | Binary | Pre‑translational | Alternative splicing removes the AP2alpha-binding motif of Synaptojanin-1 (SYNJ1), abrogating binding to AP-2 complex subunit alpha-2 (AP2A2). Isoform Synaptojanin-170 of Synaptojanin-1 (SYNJ1) is associated with clathrin-mediated endocytosis as a negative regulator of coat-membrane interaction. This isoform is virtually absent from mature neuronal synapses, where clathrin-mediated endocytosis plays a critical role and where Isoform Synaptojanin-145 of Synaptojanin-1 (SYNJ1) is by far the major synaptojanin isoform. Isoform Synaptojanin-145 of Synaptojanin-1 (SYNJ1) may be recruited early to clathrin-coated pits of synapses, either indirectly by adaptors that bind clathrin and AP-2, such as Amphiphysin (AMPH), or by interactions of endophilin family dimers with synaptic vesicle cargo, such as the vesicular glutamate transport. | ||