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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
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Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma - PIP5K1C -  Homo sapiens
LIG_PTB_Talin650653BinaryPhysicochemical compatibilityPhosphorylation of S650 in the PTB-binding motif of Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) blocks its interaction with Talin-1 (TLN1). Phosphorylation of Y649 by Src kinase enhances the interaction, possibly indirectly by inhibiting S650 phosphorylation.
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TRG_ENDOCYTIC_2649652BinaryPhysicochemical compatibilityPhosphorylation of S645 near the AP2-binding motif of Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) by Cyclin-dependent kinase 5 (Cdk5) inhibits its interaction with AP-2 complex subunit mu (AP2M1).
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