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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P12004 (4 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

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Cyclin-dependent kinase inhibitor 1DNA polymerase delta subunit 3Inhibitor of growth protein 1


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Cyclin-dependent kinase inhibitor 1 - CDKN1A -  Homo sapiens
LIG_PCNA_PIPBox_1144153BinaryPhysicochemical compatibilityPhosphorylation of T145 in the PCNA-binding motif of Cyclin-dependent kinase inhibitor 1 (CDKN1A) by RAC-alpha serine/threonine-protein kinase (AKT1) inhibits binding to Proliferating cell nuclear antigen (PCNA). As a result, Cyclin-dependent kinase inhibitor 1 (CDKN1A) no longer inhibits Proliferating cell nuclear antigen (PCNA) and blocking of DNA replication is relieved.
details
LIG_PCNA_PIPBox_1144153BinaryPhysicochemical compatibilityPhosphorylation of S146 in the PCNA-binding motif of Cyclin-dependent kinase inhibitor 1 (CDKN1A) by PKC subfamily inhibits binding to Proliferating cell nuclear antigen (PCNA). As a result, Cyclin-dependent kinase inhibitor 1 (CDKN1A) no longer inhibits Proliferating cell nuclear antigen (PCNA) and blocking of DNA replication is relieved.
details

DNA polymerase delta subunit 3 - POLD3 -  Homo sapiens
LIG_PCNA_PIPBox_1456465BinaryPhysicochemical compatibilityPhosphorylation of S458 in the PCNA-binding motif of DNA polymerase delta subunit 3 (POLD3) by cAMP subfamily reduces the affinity of binding to the Proliferating cell nuclear antigen (PCNA) and decreases the processivity of the polymerase complex.
details

Inhibitor of growth protein 1 - ING1 -  Homo sapiens
LIG_PCNA_2915BinaryPre‑translationalAlternative splicing removes the PCNA-binding motif of Isoform Variant A of Inhibitor of growth protein 1 (ING1), abrogating binding to Proliferating cell nuclear antigen (PCNA). P33-ING1b (also known as Isoform Variant A of Inhibitor of growth protein 1 (ING1)) binds specially to PCNA, resulting in a major change in subcellular localisation and the import of this isoform into the nucleus. This is theorised to act by limiting access to the PCNA-binding domain but eventually it promotes apoptosis (though this may not be its physiological effect).
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