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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P35235 (3 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

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Cytotoxic T-lymphocyte protein 4 (Mus)Sialic acid-binding Ig-like lectin 12 (Mus)


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Cytotoxic T-lymphocyte protein 4 - Ctla4 -  Mus musculus
LIG_SH2_STAT5201204SpecificityAltered binding specificityDephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4.
details

Sialic acid-binding Ig-like lectin 12 - Siglec12 -  Mus musculus
LIG_TYR_ITIM430435BinaryPre‑translationalAlternative splicing removes the ITIM (immunoreceptor tyrosine-based inhibitory motif) of Sialic acid-binding Ig-like lectin 12 (Siglec12), abrogating binding to Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11).
details
LIG_TYR_ITIM430435BinaryPre‑translationalAlternative splicing removes the ITIM (immunoreceptor tyrosine-based inhibitory motif) of Sialic acid-binding Ig-like lectin 12 (Siglec12), abrogating binding to Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11).
details
           
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