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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:Q02821 (3 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
Importin subunit alpha (Saccharomyces)Large T antigen (Simian)Regulatory protein SWI6 (Saccharomyces)


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Importin subunit alpha - SRP1 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
TRG_NLS_Bipartite_14458SpecificityDomain hidingAn intramolecular interaction between the importin beta-binding (IBB) domain and the NLS-binding pocket of Importin subunit alpha (SRP1) prevents binding of NLS cargo (e.g. Large T antigen) in the absence of Importin subunit beta-1 (KAP95) by hiding of the NLS-binding pocket. Binding of the IBB of Importin subunit alpha (SRP1) to Importin subunit beta-1 (KAP95) relieves this auto-inhibitory interaction and increases the affinity of Importin subunit alpha (SRP1) for NLS cargo.
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Large T antigen - -  Simian virus 40
TRG_NLS_MonoExtN_4126132SpecificityDomain hidingAn intramolecular interaction between the importin beta-binding (IBB) domain and the NLS-binding pocket of Importin subunit alpha (SRP1) prevents binding of NLS cargo (e.g. Large T antigen) in the absence of Importin subunit beta-1 (KAP95) by hiding of the NLS-binding pocket. Binding of the IBB of Importin subunit alpha (SRP1) to Importin subunit beta-1 (KAP95) relieves this auto-inhibitory interaction and increases the affinity of Importin subunit alpha (SRP1) for NLS cargo.
details

Regulatory protein SWI6 - SWI6 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
TRG_NLS_MonoExtN_4161167BinaryPhysicochemical compatibilityPhosphorylation of S160 adjacent to the NLS of Regulatory protein SWI6 (SWI6) decreases nuclear import of this protein by decreasing the affinity for Importin subunit alpha (SRP1).
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