switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Show inferred Group Index Colouring Info Filtered: ELM:TRG_NES (3 hits) x

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Curated inferred

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Evidence

Serine/threonine-protein kinase CBK1 - CBK1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
TRG_NES	ACE2_YEAST	122	150	Binary	Physicochemical compatibility	Phosphorylation of S137 in the NES of Metallothionein expression activator (ACE2) inhibits binding to Exportin-1 (CRM1). Phosphorylation of S137, and to a lesser extent S122, by Cbk1 directly antagonizes the interaction of Ace2 with nuclear export machinery.	details	Curated
TRG_NES	ACE2_YEAST	122	150	Binary	Physicochemical compatibility	Phosphorylation of S122 in the NES of Metallothionein expression activator (ACE2) inhibits binding to Exportin-1 (CRM1). Phosphorylation of S137, and to a lesser extent S122, by Cbk1 directly antagonizes the interaction of Ace2 with nuclear export machinery.	details	Curated
Serine/threonine-protein kinase PLK1 - PLK1 - Homo sapiens
TRG_NES_CRM1_1	MPIP3_HUMAN	189	203	Binary	Physicochemical compatibility	Phosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C).	details	Curated