Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
PKC subfamily | ||||||||
LIG_PCNA_PIPBox_1 | CDN1A_HUMAN | 144 | 153 | Binary | Physicochemical compatibility | Phosphorylation of S146 in the PCNA-binding motif of Cyclin-dependent kinase inhibitor 1 (CDKN1A) by PKC subfamily inhibits binding to Proliferating cell nuclear antigen (PCNA). As a result, Cyclin-dependent kinase inhibitor 1 (CDKN1A) no longer inhibits Proliferating cell nuclear antigen (PCNA) and blocking of DNA replication is relieved. | Curated | |
RAC-alpha serine/threonine-protein kinase - AKT1 -  Homo sapiens | ||||||||
LIG_PCNA_PIPBox_1 | CDN1A_HUMAN | 144 | 153 | Binary | Physicochemical compatibility | Phosphorylation of T145 in the PCNA-binding motif of Cyclin-dependent kinase inhibitor 1 (CDKN1A) by RAC-alpha serine/threonine-protein kinase (AKT1) inhibits binding to Proliferating cell nuclear antigen (PCNA). As a result, Cyclin-dependent kinase inhibitor 1 (CDKN1A) no longer inhibits Proliferating cell nuclear antigen (PCNA) and blocking of DNA replication is relieved. | Curated |