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Filtered:
UNIPROT:P38936 (6 hits)
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Curated
inferred
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Index
Cell cycle
Mitotic G1-G1/S phases
Motif
Protein
Start
End
Switch Type
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Information
Evidence
Cell cycle
(
KEGG - hsa04110
)
DOC_CYCLIN_1
CDN1A_HUMAN
19
22
Specificity
Competition
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
(p21) and the
M-phase inducer phosphatase 1 (CDC25A)
bind the same site on Cyclin proteins (e.g.
G1/S-specific cyclin-E1 (CCNE1)
), making their interactions mutually exclusive.
details
Curated
DOC_CYCLIN_1
MPIP1_HUMAN
11
15
Specificity
Competition
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
(p21) and the
M-phase inducer phosphatase 1 (CDC25A)
bind the same site on Cyclin proteins (e.g.
G1/S-specific cyclin-E1 (CCNE1)
), making their interactions mutually exclusive.
details
Curated
LIG_PCNA_PIPBox_1
CDN1A_HUMAN
144
153
Binary
Physicochemical compatibility
Phosphorylation of T145 in the PCNA-binding motif of
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
by
RAC-alpha serine/threonine-protein kinase (AKT1)
inhibits binding to
Proliferating cell nuclear antigen (PCNA)
. As a result,
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
no longer inhibits
Proliferating cell nuclear antigen (PCNA)
and blocking of DNA replication is relieved.
details
Curated
LIG_PCNA_PIPBox_1
CDN1A_HUMAN
144
153
Binary
Physicochemical compatibility
Phosphorylation of S146 in the PCNA-binding motif of
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
by
PKC subfamily
inhibits binding to
Proliferating cell nuclear antigen (PCNA)
. As a result,
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
no longer inhibits
Proliferating cell nuclear antigen (PCNA)
and blocking of DNA replication is relieved.
details
Curated
Mitotic G1-G1/S phases
(
Reactome - 453279
)
DOC_CYCLIN_1
CDN1A_HUMAN
19
22
Specificity
Competition
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
(p21) and the
M-phase inducer phosphatase 1 (CDC25A)
bind the same site on Cyclin proteins (e.g.
G1/S-specific cyclin-E1 (CCNE1)
), making their interactions mutually exclusive.
details
Curated
DOC_CYCLIN_1
MPIP1_HUMAN
11
15
Specificity
Competition
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
(p21) and the
M-phase inducer phosphatase 1 (CDC25A)
bind the same site on Cyclin proteins (e.g.
G1/S-specific cyclin-E1 (CCNE1)
), making their interactions mutually exclusive.
details
Curated
