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UNIPROT:P46013 (5 hits)
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Index
Cyclin-dependent kinase 1
Glycogen synthase kinase-3 beta
Motif
Protein
Start
End
Switch Type
Switch Subtype
Switch description
Information
Evidence
Cyclin-dependent kinase 1 -
CDK1
-  
Homo sapiens
LIG_FHA_2
MK67I_HUMAN
238
244
Specificity
Altered binding specificity
Phosphorylation of T238 of
MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)
by
Cyclin-dependent kinase 1 (CDK1)
primes for phosphorylation of T234 by
Glycogen synthase kinase-3 beta (GSK3B)
, which primes for phosphorylation of S230 by
GSK3B
. Triple-phosphorylated hNIFK (
MKI67IP
) binds strongly to
Antigen KI-67 (MKI67)
.
details
Curated
Glycogen synthase kinase-3 beta -
GSK3B
-  
Homo sapiens
LIG_FHA_2
MK67I_HUMAN
238
244
Specificity
Altered binding specificity
Phosphorylation of T238 of
MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)
by
Cyclin-dependent kinase 1 (CDK1)
primes for phosphorylation of T234 by
Glycogen synthase kinase-3 beta (GSK3B)
, which primes for phosphorylation of S230 by
GSK3B
. Triple-phosphorylated hNIFK (
MKI67IP
) binds strongly to
Antigen KI-67 (MKI67)
.
details
Curated
LIG_FHA_2
MK67I_HUMAN
238
244
Specificity
Altered binding specificity
Phosphorylation of T238 of
MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)
by
Cyclin-dependent kinase 1 (CDK1)
primes for phosphorylation of T234 by
Glycogen synthase kinase-3 beta (GSK3B)
, which primes for phosphorylation of S230 by
GSK3B
. Triple-phosphorylated hNIFK (
MKI67IP
) binds strongly to
Antigen KI-67 (MKI67)
.
details
Curated
LIG_FHA_2
MK67I_HUMAN
238
244
Cumulative
Rheostatic
Phosphorylation of T238 in
MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)
by
Cyclin-dependent kinase 1 (CDK1)
primes for phosphorylation of T234 by
Glycogen synthase kinase-3 beta (GSK3B)
, which primes for phosphorylation of S230 by
Glycogen synthase kinase-3 beta (GSK3B)
. Triple-phosphorylated hNIFK (
MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)
) binds strongly to
Antigen KI-67 (MKI67)
. See also
switch details
details
Curated
LIG_FHA_2
MK67I_HUMAN
238
244
Cumulative
Rheostatic
Phosphorylation of T238 in
MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)
by
Cyclin-dependent kinase 1 (CDK1)
primes for phosphorylation of T234 by
Glycogen synthase kinase-3 beta (GSK3B)
, which primes for phosphorylation of S230 by
Glycogen synthase kinase-3 beta (GSK3B)
. Triple-phosphorylated hNIFK (
MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)
) binds strongly to
Antigen KI-67 (MKI67)
. See also
switch details
details
Curated