About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:Q15303 (2 hits) x


x  Coloured by: Modifier evidence source
          Curated          inferred


x  Index
Receptor tyrosine-protein kinase erbB-4


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Receptor tyrosine-protein kinase erbB-4 - ERBB4 -  Homo sapiens
LIG_WW_1 ERBB4_HUMAN10531056SpecificityAltered binding specificityPhosphorylation-dependent binding of Receptor tyrosine-protein kinase erbB-4 (ERBB4) to the SH2 domains of Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) results in signaling activation, while binding to the WW domains of E3 ubiquitin-protein ligase Itchy homolog (ITCH) to unphopshorylated ERBB4 results in ubiquitylation, endocytosis and ultimately degradation of ERBB4.
details
Inferred
LIG_SH2_STAT5 ERBB4_HUMAN10561059SpecificityAltered binding specificityPhosphorylation-dependent binding of Receptor tyrosine-protein kinase erbB-4 (ERBB4) to the SH2 domains of Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) results in signaling activation, while binding to the WW domains of E3 ubiquitin-protein ligase Itchy homolog (ITCH) to unphopshorylated ERBB4 results in ubiquitylation, endocytosis and ultimately degradation of ERBB4.
details
Inferred
           
Please send any suggestions/comments to: switches@elm.eu.org