Please send any suggestions/comments to: switches@elm.eu.org
| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
Tyrosine-protein kinase ABL1 - ABL1 - Mus musculus | ||||||||
| LIG_WW_1 | JUN_MOUSE | 167 | 170 | Binary | Physicochemical compatibility | Phosphorylation of Y170 in the WW-binding motif of Transcription factor AP-1 (Jun) by Tyrosine-protein kinase ABL1 (Abl1) blocks binding to the E3 ubiquitin-protein ligase Itchy (Itch). As a result, Transcription factor AP-1 (Jun) is not ubiquitylated by E3 ubiquitin-protein ligase Itchy (Itch), and thus not targeted for proteasomal degradation. Regulation of transcriptional activity of Transcription factor AP-1 (Jun) by Tyrosine-protein kinase ABL1 (Abl1) required translocation of the kinase to the nucleus, which was triggered by T cell activation. | Curated | |