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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: PFAM:PF07653 (1 hits) x


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Glutamatergic synapse


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Glutamatergic synapse (KEGG - hsa04724)
LIG_SH3_3 PLCB1_HUMAN11621168BinaryPre‑translationalAlternative splicing removes the SH3-binding motif of Isoform B of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1), abrogating binding to SH3 and multiple ankyrin repeat domains protein 3 (SHANK3). PLCB1 associates with a SHANK3 complex in cardiomyocytes via its splice variant-specific C-terminal tail. Studies show that Isoform B of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) selectively mediates downstream responses initiated by Gq-coupled receptors, in particular hypertrophy and apoptosis.
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Inferred
           
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