Switch #: SWTI000600

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the SH3-binding motif of Isoform B of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1), abrogating binding to SH3 and multiple ankyrin repeat domains protein 3 (SHANK3). PLCB1 associates with a SHANK3 complex in cardiomyocytes via its splice variant-specific C-terminal tail. Studies show that Isoform B of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) selectively mediates downstream responses initiated by Gq-coupled receptors, in particular hypertrophy and apoptosis.

Participants:
(1) Isoform B of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)
(2) SH3 and multiple ankyrin repeat domains protein 3 (SHANK3)

(1) Phospholipase Cbeta1b associates with a Shank3 complex at the cardiac sarcolemma.
Grubb et al. FASEB J. (2011)

Other switches involving interfaces
Variant SH3 domain - 5 more (view)
LIG_SH3_3 - 5 more (view)