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| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
Endocytosis (KEGG - mmu04144) | ||||||||
| TRG_ENDOCYTIC_2 | PI51C_MOUSE | 644 | 647 | Binary | Pre‑translational | Alternative splicing removes the endocytosis motif of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c), abrogating binding to AP-2 complex subunit mu (Ap2m1). The direct interaction between the AP-2 complex and Isoform PIPKIgamma661 of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) (PIPKIgamma661) targets this isoform to sites of endocytosis at the plasma membrane. Consequently, this results in the generation of a highly concentrated pool of PI(4,5)P2 at these sites. | Inferred | |