Switches.ELM

Switch #:

SWTI000003

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Dephosphorylation of the PIF motif by PHLPP1/2 results in reduced stability and increased degradation of PKC. This is countered by autophosphorylation of the PIF motif, but mTORC2 might also contribute.

Participants:
(1) Isoform Beta-II of Protein kinase C beta type (PRKCB)

Interactions

Interaction #1 PRKCB - PRKCB(intramolecular)
intramolecular
Interfaces
(1) DOC_AGCK_PIF_1 motif (₆₅₆FEGFSF₆₆₁) in Isoform Beta-II of Protein kinase C beta type (PRKCB)
(2) Protein kinase domain_(342-600) in Isoform Beta-II of Protein kinase C beta type (PRKCB)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₆₆₀ on Isoform Beta-II of Protein kinase C beta type (PRKCB)) of the Isoform Beta-II of Protein kinase C beta type (PRKCB) DOC_AGCK_PIF_1 motif - Isoform Beta-II of Protein kinase C beta type (PRKCB) Protein kinase domain interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S₆₆₀: Isoform Beta-II of Protein kinase C beta type (PRKCB)

Context

Switch localisation
ELM curated: cytosol, internal side of plasma membrane

References

(1) Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.
Brognard et al. J. Biol. Chem. (2009)