Switch #: SWTI000004

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of T329 in the Pin1-binding motif of Alpha-globin transcription factor CP2 (TFCP2) induces binding to Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), which isomerises the peptide bonds at the nearby-phosphorylated SP motifs (S291 and S309) to the trans configuration, thereby facilitating their dephosphorylation, which is required for the transcriptional activity of Alpha-globin transcription factor CP2 (TFCP2).

Participants:
(1) Alpha-globin transcription factor CP2 (TFCP2)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

(1) Prolyl isomerase Pin1 regulates transcription factor LSF (TFCP2) by facilitating dephosphorylation at two serine-proline motifs.
Saxena et al. J. Biol. Chem. (2010)

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)