About Help Definitions Submit Search Analyse Browse Home

Switch #:
Switch type:
Switch subtype:
Physicochemical compatibility

Phosphorylation of T130 in the PLK-docking motif of M-phase inducer phosphatase 3 (CDC25C) by Cyclin-dependent kinase 1 (CDK1)-Cyclin AB subfamily generates a recruitment site for Serine/threonine-protein kinase PLK1 (PLK1), which then phosphorylates M-phase inducer phosphatase 3 (CDC25C). This results in inactivation of the NES of M-phase inducer phosphatase 3 (CDC25C), thereby promoting its nuclear localization.

(1) M-phase inducer phosphatase 3 (CDC25C)
(2) Serine/threonine-protein kinase PLK1 (PLK1)

Interaction #1 CDC25C - PLK1

(1) ELM:LIG_PLK motif (129STP131) in M-phase inducer phosphatase 3 (CDC25C)
(2) POLO box duplicated region (417-584) in Serine/threonine-protein kinase PLK1 (PLK1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T130 on M-phase inducer phosphatase 3 (CDC25C)) of the M-phase inducer phosphatase 3 (CDC25C) LIG_PLK motif - Serine/threonine-protein kinase PLK1 (PLK1) POLO box duplicated region interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: T130: Cyclin-dependent kinase 1 (CDK1)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T130 : Cyclin-dependent kinase 1 (CDK1).


(1) Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.
Elia et al. Science (2003)

See also

Other switches involving participants
Serine/threonine-protein kinase PLK1 (PLK1) - 1 more (view)
M-phase inducer phosphatase 3 (CDC25C) - 2 more (view)

Other switches involving interfaces
ELM:LIG_PLK - 1 more (view)
POLO box duplicated region - 1 more (view)

Loading visualisation

Please send any suggestions/comments to: switches@elm.eu.org