Switches.ELM

Switch #:

SWTI000006

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S50 in the PLK-docking motif of M-phase inducer phosphatase 2 (CDC25B) by Cyclin-dependent kinase 1 (CDK1)-Cyclin AB subfamily generates a recruitment site for Serine/threonine-protein kinase PLK1 (PLK1), which then phosphorylates and activates M-phase inducer phosphatase 2 (CDC25B).

Participants:
(1) M-phase inducer phosphatase 2 (CDC25B)
(2) Serine/threonine-protein kinase PLK1 (PLK1)

Interactions

Interaction #1 CDC25B - PLK1

Interfaces
(1) ELM:LIG_PLK motif (₄₉SSP₅₁) in M-phase inducer phosphatase 2 (CDC25B)
(2) POLO box duplicated region_(417-584) in Serine/threonine-protein kinase PLK1 (PLK1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₅₀ on M-phase inducer phosphatase 2 (CDC25B)) of the M-phase inducer phosphatase 2 (CDC25B) LIG_PLK motif - Serine/threonine-protein kinase PLK1 (PLK1) POLO box duplicated region interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S₅₀: Cyclin-dependent kinase 1 (CDK1)

Context

Switch localisation

Switch pathways
Curated: Cell cycle

References

(1) Study of the docking-dependent PLK1 phosphorylation of the CDC25B phosphatase.
Lobjois et al. Biochem. Biophys. Res. Commun. (2011)