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Physicochemical compatibility

Phosphorylation of S50 in the PLK-docking motif of M-phase inducer phosphatase 2 (CDC25B) by Cyclin-dependent kinase 1 (CDK1)-Cyclin AB subfamily generates a recruitment site for Serine/threonine-protein kinase PLK1 (PLK1), which then phosphorylates and activates M-phase inducer phosphatase 2 (CDC25B).

(1) M-phase inducer phosphatase 2 (CDC25B)
(2) Serine/threonine-protein kinase PLK1 (PLK1)

Interaction #1 CDC25B - PLK1

(1) ELM:LIG_PLK motif (49SSP51) in M-phase inducer phosphatase 2 (CDC25B)
(2) POLO box duplicated region (417-584) in Serine/threonine-protein kinase PLK1 (PLK1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S50 on M-phase inducer phosphatase 2 (CDC25B)) of the M-phase inducer phosphatase 2 (CDC25B) LIG_PLK motif - Serine/threonine-protein kinase PLK1 (PLK1) POLO box duplicated region interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S50: Cyclin-dependent kinase 1 (CDK1)


(1) Study of the docking-dependent PLK1 phosphorylation of the CDC25B phosphatase.
Lobjois et al. Biochem. Biophys. Res. Commun. (2011)

See also

Other switches involving participants
Serine/threonine-protein kinase PLK1 (PLK1) - 1 more (view)
M-phase inducer phosphatase 2 (CDC25B) - 2 more (view)

Other switches involving interfaces
ELM:LIG_PLK - 1 more (view)
POLO box duplicated region - 1 more (view)

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