Switch #: SWTI000022

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Hydroxylation of P402 in the VHL-binding motif of Hypoxia-inducible factor 1-alpha (HIF1A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.

Participants:
(1) Hypoxia-inducible factor 1-alpha (HIF1A)
(2) Von Hippel-Lindau disease tumor suppressor (VHL)

(1) Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Hon et al. Nature (2002)

(2) Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.
Hirsilä et al. J. Biol. Chem. (2003)

Other switches involving participants
Hypoxia-inducible factor 1-alpha (HIF1A) - 2 more (view)
Von Hippel-Lindau disease tumor suppressor (VHL) - 5 more (view)

Other switches involving interfaces
DEG_ODPH_VHL_1 - 5 more (view)
von Hippel-Lindau disease tumour suppressor protein - 5 more (view)