Switch #: SWTI000021

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of T2511 in the degron of Neurogenic locus notch homolog protein 1 (NOTCH1) induces binding to the F-box/WD repeat-containing protein 7 (FBXW7) protein, which recruits it to the SCF ubiquitin ligase complex where it is marked for degradation.

Participants:
(1) Neurogenic locus notch homolog protein 1 (NOTCH1)
(2) F-box/WD repeat-containing protein 7 (FBXW7)

(1) The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog.
Oberg et al. J. Biol. Chem. (2001)

(2) SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation.
Wu et al. Mol. Cell. Biol. (2001)

Other switches involving participants
F-box/WD repeat-containing protein 7 (FBXW7) - 8 more (view)
Neurogenic locus notch homolog protein 1 (NOTCH1) - 3 more (view)

Other switches involving interfaces
DEG_SCF_FBW7_2 - 1 more (view)
WD domain, G-beta repeat - 36 more (view)