Switch #: SWTI000027

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S412 in the Pin1-binding motif of Tumor protein p73 (TP73) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Tumor protein p73 (TP73)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

(1) Pin1 links the activities of c-Abl and p300 in regulating p73 function.
Mantovani et al. Mol. Cell (2004)

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Tumor protein p73 (TP73) - 6 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)