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Switch #:
SWTI000028
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T442 in the Pin1-binding motif of Tumor protein p73 (TP73) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Tumor protein p73 (TP73)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 TP73 - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (439SAATPN444) in Tumor protein p73 (TP73)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T442 on Tumor protein p73 (TP73)) of the Tumor protein p73 (TP73) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Pin1 links the activities of c-Abl and p300 in regulating p73 function.
Mantovani et al. Mol. Cell (2004)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Tumor protein p73 (TP73) - 6 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)




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