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Switch #:
SWTI000035
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T58 in the Pin1-binding motif of Myc proto-oncogene protein (MYC) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Myc proto-oncogene protein (MYC)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 MYC - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (55LLPTPP60) in Myc proto-oncogene protein (MYC)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T58 on Myc proto-oncogene protein (MYC)) of the Myc proto-oncogene protein (MYC) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T58 : GSK-3_group, Mitogen-activated protein kinase 1 (MAPK1), Glycogen synthase kinase-3 beta (Gsk3b), Mitogen-activated protein kinase 10 (MAPK10), Glycogen synthase kinase-3 alpha (GSK3A), Glycogen synthase kinase-3 beta (GSK3B).

Context
Switch localisation
ELM curated: nucleus, cytosol
Inferred: cytoplasm, nucleoplasm
References

(1) A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.
Yeh et al. Nat. Cell Biol. (2004)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Myc proto-oncogene protein (MYC) - 4 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)


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