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Switch #:
SWTI000034
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S374 in the Pin1-binding motif of Proto-oncogene c-Fos (Fos) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) Proto-oncogene c-Fos (Fos)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interactions
Interaction #1 Fos - Pin1

Interfaces
(1) DOC_WW_Pin1_4 motif (371SLSSPT376) in Proto-oncogene c-Fos (Fos)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S374 on Proto-oncogene c-Fos (Fos)) of the Proto-oncogene c-Fos (Fos) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.
Monje et al. J. Biol. Chem. (2005)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) - 28 more (view)
Proto-oncogene c-Fos (Fos) - 3 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)




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